Fig. 3.

Experimental validation of PAW. Wheel running activity was assessed using PAW. A. Mean hourly running distance recorded from across one week for cages of male (n = 6 cages; 5 mice per cage) and female (n = 6 cages, 5 mice per cage) mice. Lights were turned on at ZT0 and turned off at ZT12. B. Male and female mice recorded greater running activity during the dark phase, while lights were off, than during the light phase. C. The mean distance travelled per cage increased over the course of the week.