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. 2023 Dec 18;10(1):e23915. doi: 10.1016/j.heliyon.2023.e23915

Fig. 7.

Fig. 7

Prediction of TLS score in immunotherapy response. a. Circos plot showing the distribution of six immune subtypes in two clusters and TLS score groups in pan-cancer. b. Box plot showing the TLS score in patients with or without immunotherapy response in the GSE35640 dataset. The Wilcoxon rank test evaluated statistical importance. c. Overall survival of patients with high TLS-scores was compared with those with low TLS-scores using Kaplan–Meier survival curve in IMvigor210 dataset. A log-rank test assessed statistical significance. Box plot showing the TLS score in patients with complete response/partial response and stable disease/progressive disease. The Wilcoxon rank test assessed statistical significance. d. Box plot showing the TLS score in patients with or without immunotherapy response in the GSE165252 dataset. The Wilcoxon rank test evaluated statistical importance. e. The survival of patients with high TLS-scores was compared with those with low TLS-scores using the Kaplan–Meier survival curve in the GSE78220 dataset. A log-rank test assessed statistical significance. Box plot showing the TLS score in patients with complete response/partial response and stable disease/progressive disease. The Wilcoxon rank test assessed statistical significance. f. Box plot showing the TLS score in patients with complete response/partial response and stable disease/progressive disease in the GSE91061 dataset. The Wilcoxon rank test assessed statistical significance.