eTable 1. Areas of indication and types of application of DiGA.
| DiGA | Type of application | Listing status | Indications | Contraindications | Duration of use | Costs (€) per quarter | Foreign language |
| Depression | |||||||
| Deprexis | Web application*1 | Final listing in the DiGA Directory of the German Federal Institute for Drugs and Medical Devices (BfArM) | ● Mild to severe depressive episode (F32.0, F32.1, F32.2) ● Recurrent depressive disorder (F33.0, F33.1, F33.2) |
● Schizophrenia (F20) ● Acute transient psychotic disorder (F23) ● Schizoaffective disorder (F25) ● Bipolar disorder (F31) ● Other symptoms and signs involving emotional state (R45.8) ● Suicidal risk |
At least 90 days(1–2 x per week, minimum duration 30 min each) | 210.00 | ELL, ENG, FRA, ITA, POR, SPA, SWE, ZHO |
| Selfapy’s Online course for depression | Web application*1 + smartphone app*2 |
Final listing in the DiGA Directory | ● Mild and moderate depressive episode (F32.0, F32.1) ● Recurrent depressive disorder (F33.0, F33.1) |
● Dementia in Alzheimer dis. (F00) ● Alcohol dependence and withdrawal syndrome (F10.2, F10.3) ● Schizophrenia (F20) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3, F33.3) ● Acute suicidality |
At least 90 days | 217.18 | – |
| Novego: coping with depression | Web application*1 | Provisional listing in the DiGA Directory; trial period: 10.10.2021–09.10.2022 | ● Mild and moderate depressive episode (F32.0, F32.1) ● Recurrent depressive disorder (F33.0, F33.1) ● Dysthymia (F34.1) |
● Organic mental disorder (F0x) ● Dependence disorder (F1x.2) ● Psychotic disorder (F2x) ● Bipolar disorder (F31) ● Mania (F30.0) ● Suicidality in the last 4 weeks |
At least 90 days | 249.00 | – |
| Edupression.com | Web application*1 | Provisional listing in the DiGA Directory; trial period: 26.12.2022–25.08.2022 | ● Mild and moderate depressive episode (F32.0, F32.1) ● Recurrent depressive disorder (F33.0, F33.1) |
● Schizotypal disorder (F21) ● Persistent delusional disorder (F22) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3, F33.3) ● Suicidality ● Psychotic disorder |
At least 90 days | 357.00 Follow-up costs: 178.50 |
ENG |
| Elona therapy Depression | Web application*1 + smartphone app*2 |
Provisional listing in the DiGA Directory; trial period: 26.12.2022–25.12.2023 | ● Mild and moderate depressive episode (F32.0, F32.1) ● Recurrent depressive disorder (F33.0, F33.1) ● Dysthymia (F34.1) |
● Psychotic disorder (F2x) ● Bipolar disorder (F31) ● Mania (F30) ● Severe depressive episode with psychotic symptoms (F32.3, F33.3) ● Acute suicidality |
At least 90 days | 535.49 | – |
| Anxiety disorders | |||||||
| Invirto – The Therapy for Anxiety | Smartphone app*2 *3 | Final listing in the DiGA Directory | ● Agoraphobia with/without panic disorder (F40.00, F40.01) ● Social phobia (F40.1) ● Panic disorder (F41.0) |
● Organic mental disorder (F0x) ● Substance dependence disorder (F1x) ● Psychotic disorder (F2x) ● Mania (F30) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3 and F33.3), H54, H81, H82, H91.3, I08, I09, I20, I22, I25, I45, I49, I50, I69, R42 Relative contraindications: F32.2, F33.2, F06.3, F06.4, F43, F44, G40–47, H90, I10–15, J40–47 ● Pregnancy |
90 days, with an average of 8 weeks | 620.00 | – |
| Mindable: Panic disorder and agoraphobia | Smartphone app*2 | Final listing in the DiGA Directory | ● Agoraphobia with/without panic disorder (F40.0) ● Panic disorder (F41.0) |
● Acute psychoactive substance intoxication (F1x.0) ● Psychotic disorder (F2x) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3, F33.3) ● Acute suicidal ideation |
90 days, at least 8 weeks | 576.00 | ENG, FRA |
| Selfapy‘s online course for generalized anxiety disorder | Web application*1 + smartphone app*2 |
Final listing in the DiGA Directory | ● Generalized anxiety disorder (F41.1) ● Approved only for women; for male patients on a self-pay basis |
● Schizophrenia (F20) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3, F33.3) ● Dementia in Alzheimer dis. (F00) ● Alcohol dependence and withdrawal syndrome (F10.2, F10.3) ● Acute suicidality |
At least 90 days(at least 1 x/w for approx. 30–45 min)) | 479.52 | – |
| Velibra | Web application*1 | Final listing in the DiGA Directory | ● Agoraphobia with panic disorder (F40.01) ● Social phobia (F40.1) ● Panic disorder (F41.0) ● Generalized anxiety disorder (F41.1) |
● Schizophrenia (F20) ● Acute transient psychotic disorderr (F23) ● Schizoaffective disorder (F25), ● Bipolar disorder (F31) ● Other symptoms and signs involving emotional state (R45.8) ● Suicidal ideation |
At least 90 days(1–2 x/week at least 30 min each) | 230.00 | ENG |
| HelloBetter Panic | Web application*1 | Final listing in the DiGA Directory | ● Agoraphobia with panic disorder (F40.01) ● Panic disorder (F41.0) |
● Organic mental disorder (F0x) ● Substance dependence disorders (F1x) ● Psychotic disorder (F2x) ● Mania (F30) ● Bipolar disorder (F31) ● Severe depressive episode with psychotic symptoms (F32.3 and F33.3) ● Dissociative disorder (F44) ● Suicidality ● Psychotherapy naivety |
12 weeks | 599.00 | – |
| Substance use disorders | |||||||
| Nichtraucher-Helden app | Smartphone app*2 | Provisional listing in the DiGA Directory; trial period:03.07.2021–02.07.2022 | ● Nicotine dependence (F17.2) | ● Acute transient psychotic disorder (F23) ● Schizoaffective disorder (F25) ● Bipolar disorder (F31) ● Depressive episode or recurrent depressive disorder (F32, F33) ● Delirium (F05) ● Other (non-phobic) anxiety disorders (F41) ● Acute depression or suicidality ● Acute delirium or psychotic disorder |
At least 90 days | Initial costs: 329.00 Follow-up costs: 119.00 |
– |
| Vorvida | Web application*1 | Final listing in the DiGA Directory | ● Harmful use of alcohol and alcohol dependence (F10.1, F10.2) | ● Schizophrenia (F20) ● Acute transient psychotic disorder (F23) ● Schizoaffective disorder (F25) ● Other symptoms and signs involving emotional state (R45.8) |
At least 90 days(1–2 x/week at least 30 min each) | 192.01 | ENG |
| Sleep disorders | |||||||
| Somnio | Web application*1 + smartphone app*2 *4 |
Final listing in the DiGA Directory | ● Nonorganic insomnia (F51.0) | ● Bipolar disorder (F31) ● Epilepsy ● Suicidality |
At least 90 days | 224.99 | ENG, FRA |
| HelloBetter Sleep | Web application*1 | Provisional listing in the DiGA Directory; trial period: 18.12.2022–17.12.2023 | ● Nonorganic insomnia (F51.0) ● Disorders of initiating and maintaining sleep (G47.0) |
● Acute transient psychotic disorder (F23) ● Bipolar disorder (F31) ● Epilepsy (G40) ● Suicidality |
8 units, 45–60 min each | 599.00 | – |
| Other | |||||||
| HelloBetter Stress and Burnout | Web application*1 | Final listing in the DiGA Directory | ● Problems related to life management difficulty (Z73) | ● Schizophrenia spectrum disorders ● Dissociative disorder ● Suicidality |
At least 90 days | 235.00 | – |
| HelloBetter Vaginismus Plus | Web application*1 *5 | Final listing in the DiGA Directory | ● Nonorganic vaginismus (F52.5) ● Nonorganic dyspareunia (F52.6) |
● Acute transient psychotic disorder (F23), ● Suicidality |
At least 90 days | 599.00 | – |
| HelloBetter ratiopharm Chronic Pain | Web application*1 | Provisional listing in the DiGA Directory; trial period:18.12.2021–17.07.2023 | ● Persistent somatoform pain disorder(F45.40) ● Chronic pain disorder with somatic and psychological factor(F45.41), ● Back pain (M54) ● Fibromyalgia (M79.7) ● Chronic intractable pain(R52.1) ● Other chronic pain (R52.2) |
● Suicidality ● Exclusively acute pain ● Cancer pain |
At least 90 days | 599.00 | – |
*1 Web application (internet-enabled end device)
*2 Smartphone app (Android-/iOS smartphone)
*3: VR glasses (provided by the manufacturer; reimbursable)
*4 Integration with Sleep Tracker app possible, non-reimbursable, approx. 50–150 €)
*5 A vaginal dilator set is required for optimum use (reimbursable on request via a separate prescription).
ELL, Greek; ENG, English; FRA, French; ITA, Italian; POR, Portuguese; SPA, Spanish; SWE, Swedish; ZHO, Chinese