eTable 2. Application content and information for treatment providers.
| Digital health application (DiGA) | Panel doctor participation required (designated activities) | Application content/ therapeutic principles | Proof of patient-relevant improvements of structure and processes | Trial access for treatment providers |
| Depression | ||||
| Deprexis | No | ● Interactive online-based self-help program to complement care as usual ● Based on methods of psychotherapy, especially cognitive behavioral therapy (CBT) |
No | For 3 days (https://ehealth.servier.de/diga-manager/suche) |
| Selfapy’s online course for depression | No | ● Personalized online course, based on CBT ● Therapeutic content is worked on independently by the patient ● Individual lessons (e.g., dealing with negative thoughts, creating a positive daily structure, relaxation techniques, sleep problems, strategies for preventing relapse) ● Teaching by means of audio and video clips, texts, and exercises ● Customization of content to the user‘s personal situation ● Continuous monitoring by a personal psychologist (via messaging function) |
No | Tel.: +49 30 120834114 E-mail: aerzte@selfapy.de |
| Novego: Coping with depression |
No | ● Online support program based on CBT ● Customization on personal circumstances of the participants ● Teaching content in the form of texts, videos, audio, and interactive exercises ● The Novego psychologist team can be contacted by a message once a week ● 24-hour crisis hotline |
No | E-mail: info@novego.de |
| Edupression.com | No | ● Digital health application, based on CBT ● User-adapted delivery of therapy content between regular therapy sessions ● Teaching in the form of texts, videos, audio, and interactive exercises ● „”Interlinked” therapy offering alongside ongoing outpatient therapy |
● Improvement in level of functioning ● Improvement in treatment adherence |
Online dummy: (https://app.edupression.com/welcome?lang=1 Free basic version: https://app.edupression.com/register) |
| Elona therapy Depression |
● Personalization of the treatment program for patients ● Monitoring + evaluation |
● Digital health application, based also on CBT ● (Psychoeducational) therapy content in a “playful” way ● Monitoring of therapy using a proprietary emotional state diagram |
No | Online form (https://www.elona.health/elona-therapy-fachkreise) |
| Anxiety disorder | ||||
| Invirto – The Therapy for Anxiety | ● Manualized therapy, free advanced training (approx. 2 h with certificate), provision of accompanying therapy hours in accordance with the current legal requirements ● Overview of patient progress and care data |
● Learning with an app and virtual reality glasses, under the guidance of psychotherapists or physicians, to deal with high levels of tension, anxious thoughts and fearful situations, among others ● Based on CBT with exposure training |
No | Trial access upon participation in a free 1.5-hour training session (https://invirto.de/fuer-behandler/) |
| Mindable: Panic Disorder and Agoraphobia |
No | ● Based on CBT ● Psychoeducation, getting used to physical symptoms (habituation through targeted symptom provocation), in vivo confrontation ● Live recording of the progression of anxiety during confrontation exercises ● Self-monitoring of anxiety-related symptoms, events, and behavior |
● Autonomous health action (patient sovereignty) ● Coping with illness-related difficulties in daily life |
Online form (https://www.mindable.health/fachkreise/) |
| Selfapy’s online course for generalized anxiety disorder | No | ● Online course, based on CBT ● Independent processing of therapeutic content through lessons (e. g., dealing with automatic thoughts, anxiety reactions and physical symptoms; exposure exercises and mindfulness exercises) ● Teaching by means of audio and video clips, texts, and exercises ● Customization of content ● Continuous monitoring by a psychologist (can be contacted via messaging function) |
No | Online form (https://www.selfapy.com/fuer-aerzte) |
| Velibra | No | ● Based on CBT, consists of 6 modules in addition to care as usual | Reducing treatment-related expenses and burdens for patients and relatives | Online form (https://de.velibra.com/kontakt/#bob-frame) |
| HelloBetter Panic | No | ● Web application based on CBT ● Psychoeducation on anxiety, panic disorder and agoraphobia ● Independent practice of exercises (interoceptive and in vivo exposures, cognitive restructuring, relaxation exercises, and relapse prevention) ● Diary, fictitious cases |
No | Online form (https://hellobetter.de/fachkreise/) |
| Substance use disorders | ||||
| NichtraucherHelden app | No | ● Non-smoking coaching with learning modules, relaxation techniques, distraction options, and motivation, based on CBT | No | Online form (https://www.nichtraucherhelden.de/pages/doctors-info.jsf) |
| Vorvida | No | ● Based on CBT ● Virtual dialogue |
Autonomous health action (patient sovereignty) | Online form (https://de.vorvida.com/#bob-frame) |
| Sleep disorders | ||||
| Somnio | ● Step 1: Motivation ● Step 2: Monitoring (optional, by discussion or report of the application 5–10 min); ● Step 3: Analysis (reviewing the report and evaluating the treatment success and initiating further measures, if needed (5–10 min) |
● Behavioral therapy self-help program, sleep diary, relaxation techniques, sleep hygiene ● Learning e.g. how to optimize sleep times and the sleep-wake rhythm, management of sleep-preventing thoughts, relaxation techniques |
No | Online form (https://somn.io/fachpersonen/) |
| HelloBetter Sleep | No | ● Behavioral therapy self-help program, sleep diary, relaxation techniques, sleep hygiene, fictitious persons as a reference for therapy ● Psychoeducation |
No | Online form (https://hellobetter.de/fachkreise/) |
| Other offerings | ||||
| HelloBetter Stress and Burnout | No | ● Interactive, psychological therapy program in the format of an online course ● Seven units to be completed weekly; one refresher unit after the end of the course ● Psychoeducation by means of text, videos and audio ● Teaching of CBT strategies (problem-solving techniques, behavioral activation, emotion regulation strategies, among others) ● Online diary, companion app, repeated symptom checks, monitoring progress ● Written feedback from psychologists within 24 h after completion of a unit ● Psychologists can be reached via messaging function |
No | Online form (https://hellobetter.de/fachkreise/) |
| HelloBetter Vaginismus Plus | No | ● Online program based on CBT (strategies for dealing with distressing thoughts and feelings, relaxation and pelvic floor exercises, sensuality training [“sensate focus”], as well as step-by-step exercises involving vaginal insertion of dilators, among others) ● Psychoeducation by means of text, videos and audio ● Special focus on step-by-step exercises, involving vaginal insertion of dilators with the associated reduction of avoidance behavior and development of positive sexual experiences ● Online diary, symptom checks, companion app ● Fictitious course partners accompany users through the online program and serve as inspiration and assistance in completing the exercises ● Written feedback from psychologists ● Psychologists can be reached via messaging function |
No | Online form (https://hellobetter.de/fachkreise/) |
| HelloBetter ratiopharm Chronic Pain | No | ● Interactive psychological online program, based on acceptance and commitment therapy (ACT) and CBT (mindfulness techniques, cognitive restructuring, values work, and instructions for self-reflection, among others) ● Psychoeducation by means of text, videos and audio ● Teaching exercises to be integrated into everyday life ● In addition: online diary, companion app and repeated symptom checks to monitor personal progress |
No | Online form (https://hellobetter.de/fachkreise/) |