Table II.
Diagnostic and therapeutic significance of exosomal circRNAs in gastrointestinal cancer.
| Cancer type | CircRNA | CircBase ID | Expression | Source | Case no. | Potential function | AUC | Sensitivity (%), specificity (%) | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|
| GC | Hsa_circ_0015286 | Hsa_circ_0015286 | ↑ | Plasma- | 60 | Diagnosis and | 0.778 | 82.1, 65.7 | (118) |
| derived | prognosis | ||||||||
| EVs | |||||||||
| GC | CircRNA CDR1as | - | ↓ | Plasma- | 65 | Diagnosis and | 0.786 | - | (119 |
| derived | prognosis | ||||||||
| EVs | |||||||||
| GC | Hsa_circ_0000419 | Hsa_circ_0000419 | ↓ | Plasma- | 96 | Diagnosis and | 0.840 | 68.2, 88.4 | (120) |
| derived | prognosis | ||||||||
| EVs | |||||||||
| CRC | CircNRIP1 | Hsa_circ_0004771 | ↑ | Serum- | 170 | Diagnosis | 0.816 | 81.4, 74.3 | (121) |
| derived | |||||||||
| EVs | |||||||||
| CRC | Circ-PNN | Hsa_circ_0101802 | ↑ | Serum- | 88 | Diagnosis | 0.855 | 89.8, 73.9 | (122) |
| derived | |||||||||
| EVs | |||||||||
| CRC | CircGAPVD1 | Hsa_circ_0003270 | ↑ | Plasma- | 78 | Diagnosis | 0.7662 | 75.6, 71.7 | (123) |
| derived | |||||||||
| EVs | |||||||||
| GC | CircFCHO2 | - | ↑ | Serum- | - | Potential | - | - | (126) |
| derived | therapeutic | ||||||||
| EVs | target | ||||||||
| GC | Circ29 | Hsa_circ_0044366 | ↑ | Plasma- | - | Potential | - | - | (127) |
| derived | therapeutic | ||||||||
| EVs | target | ||||||||
| CRC | CircPABPC1 | Has-circ-0085159 | ↑ | Serum- | 60 | Potential | - | - | (128) |
| derived | therapeutic | ||||||||
| EVs | target | ||||||||
| GC | CircDIDO1 | Hsa_circ_0061137 | ↓ | Cell | 17 | Potential | - | - | (130) |
| superna | therapeutic | ||||||||
| tant- | target | ||||||||
| derived | |||||||||
| EVs | |||||||||
| GC | CircSTAU2 | Hsa_circ_0001811 | ↓ | Cell | 56 | Potential | - | - | (131) |
| superna | therapeutic | ||||||||
| tant- | target | ||||||||
| derived | |||||||||
| EVs | |||||||||
| CRC | Hsa_circ_0005615 | Hsa_circ_0005615 | ↑ | Serum- | 70 | Potential | - | - | (132) |
| derived | therapeutic | ||||||||
| EVs | target |
GC, gastric cancer; CRC, colorectal cancer; circRNA, circular RNA; AUC, area under ROC curve; EV, extracellular vesicle; ↑, upregulation; ↓, downregulation.