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. 2023 Dec 28;51(2):34. doi: 10.3892/or.2023.8693

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — SENP1 regulates ferroptosis in HNSCC cells. (A) Reverse transcription-quantitative PCR detected SENP1 expression levels after erastin (10 µm, 24 h) treatment in sh-SENP1 and oe-SENP1. (B and C) Western blotting detected SENP1 expression levels after erastin (10 µm, 24 h) treatment in sh-SENP1 and oe-SENP1. (D-G) After erastin (10 µm, 24 h) treatment in HNSCC cells, SENP1 regulated the (D) cell viability, (E) GSH, (F) MDA and (G) levels of iron. *P<0.05, **P<0.01 and ***P<0.001. SENP1, SUMO-specific peptidase 1; HNSCC, head and neck squamous cell carcinoma; Ctrl, control; shRNA, short hairpin RNA; NC, negative control; oe, overexpressing; GSH, glutathione; MDA, malondialdehyde.