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. 2023 Dec 28;51(2):34. doi: 10.3892/or.2023.8693

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Copyright: © Xu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 9. — Interaction between SENP1 and ACSL4 in CAL-27 cells. (A) Co-immunoprecipitation followed by western blot analysis indicated that SENP1 and ACSL4 interacted in HNSCC cells. (B and C) Western blot analysis detected changes in ACSL4 after SENP1 silencing. (D) SUMOylation analysis of ACSL4 in the control group and SENP1 in the silence group. (E and F) Western blot detected ferroptosis-related protein SLC7A11 expression after SENP1 silencing. (E and G) Western blotting detected ferroptosis-related protein GPX4 expression after SENP1 silencing. **P<0.01. SENP1, SUMO-specific peptidase 1; ACSL4, acyl CoA synthetase long chain 4; HNSCC, head and neck squamous cell carcinoma; SLC7A11, solute carrier family 7 member 11; GPX4, glutathione peroxidase 4; NC, negative control; shRNA, short hairpin RNA.