Table 2.

Protein copy number and concentration following 24-h treatment with cocaine (10 μM) or vehicle as determined by proteomics analysis

Protein	Vehicle		Cocaine
	Copy Number	Concentration (nM)	Copy Number	Concentration (nM)
CEACAM1	59,626 ± 10,789	43.9 ± 7.5	106,220 ± 7,458**	86.6 ± 4.4**
COL6A1	206,854 ± 12,118	152.2 ± 3.7	131,021 ± 14,120**	106.9 ± 11.7**
CTSB	8,484,178 ± 416,822	6,252.0 ± 355.4	6,593,383 ± 408,852**	5,377.0 ± 230.0*
HPX	6,543,012 ± 138,928	4,821.0 ± 139.0	4,814,035 ± 116,364****	3,931.0 ± 184.8**
ICAM	676,996 ± 14,380	499.0 ± 24.0	721,746 ± 23,606*	588.8 ± 7.0**
MIF	3,493,966 ± 119,612	2,573.0 ± 39.4	4,902,856 ± 535,590*	3,996.0 ± 358.4**
PECAM	1,202,038 ± 59,972	885.6 ± 46.24	956,743 ± 10,063**	780.8 ± 9.6*
PICALM	1,014,023 ± 21,188	747.1 ± 20.5	788,182 ± 30,189***	643.2 ± 25.7**
NRP2	287,851 ± 21,441	212.0 ± 13.9	186,651 ± 2,301**	152.3 ± 3.6**
VTN	1,208,330 ± 68,554	890.8 ± 65.2	862,826 ± 6,116***	704.3 ± 20.8**
VWF	584,018 ± 20,536	430.1 ± 9.7	484,891 ± 17,129**	395.6 ± 11.0*

Mean ± standard deviation are shown. Asterisks indicate statistical significance in cocaine treated cells relative to vehicle. Paired T-test. COL6A1, Collagen Type VI Alpha 1 Chain. CTSB Cathepsin B. HPX Hemopexin. MIF Macrophage Migration Inhibitory Factor. PICALM Phosphatidylinositol Binding Clathrin Assembly Protein. NRP2 Neuropilin 2. VTN Vitronectin. VWF Von Willebrand Factor. *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.0001