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. 2024 Jan 10;23:11. doi: 10.1186/s12943-023-01924-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — FANCI knockdown affected R-loop distribution inhibiting the Ras signaling pathway. A Genome-wide R-loop signal profile for PC-9. B The percentages of R-loop peaks are distributed as intergenic, promoter, genebody, and terminator regions. C The difference in FANCI expression between tumor and normal control tissues from TCGA-LUAD (Wilcoxon rank test), and the difference in the overall survival probability between patients with high and low FANCI expression (log-rank test). D shRNAs induced gene silencing, reducing FANCI mRNA and protein levels (Student’s t-test). E Comparison of R-loop signal profile between PC-9 and PC-9 with FANCI knockdown. F The proportion of different R-loop peaks in intergenic, promoter, genebody, and terminator regions between PC-9 and PC-9 with FANCI knockdown. G The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis for genes with a statistically significant difference in the R-loop distribution between control and FANCI-knockdown PC-9 cells. H-I FANCI silencing decreased the protein levels of RasGRF1, p-PI3K, p-AKT, p-IKK, p-65 (H), and p-Raf1, p-MEK, and p-ERK in PC-9 cells (I). Transcription start site (TSS) and transcription termination site (TTS). (*p < .05, **p < .01, ***p < .001)