Table 2.

Risk of AVC progression for RC quartile groups

RC	Events/No. at risk	Model 1 HR (95% CI)	P value	Model 2 HR (95% CI)	P value	Model 3 HR (95% CI)	P value	Model 4 HR (95% CI)	P value
Quartile 1	110/1409	Reference	1.0	Reference	1.0	Reference	1.0	Reference	1.0
Quartile 2	135/1377	1.251 (0.970–1.614)	0.085	1.195 (0.925–1.545)	0.173	1.174 (0.906–1.522)	0.225	1.169 (0.899–1.520)	0.245
Quartile 3	160/1411	1.428 (1.116–1.829)	0.005	1.322 (1.028–1.701)	0.030	1.282 (0.988–1.664)	0.062	1.277 (0.977–1.667)	0.073
Quartile 4	163/1400	1.755 (1.363–2.261)	< 0.001	1.546 (1.188–2.012)	0.001	1.481 (1.120–1.958)	0.006	1.474 (1.104–1.968)	0.008
RC, mg/dL	568/5597	1.021 (1.011–1.031)	< 0.001	1.016 (1.005–1.026)	0.004	1.013 (1.002–1.025)	0.022	1.013 (1.002–1.025)	0.025

Model 1: Adjusted for age, race and sex. Model 2: Adjusted for Model 1 covariates plus antihypertensive medication use, BMI, CRP, drinking status, eGFR, FG, hypoglycemic medication use, lipid-lowering medication use, SBP and smoking status. Model 3: Adjusted for Model 2 covariates plus LDL-C. Model 4: Adjusted for Model 2 covariates plus HDL-C

AVC aortic valve calcium, BMI body mass index, CI confidence interval, CRP C-reactive protein, eGFR estimate glomerular filtration rate, FG fasting glucose, HDL-C high-density lipoprotein cholesterol, HR hazard ratio, LDL-C low-density lipoprotein cholesterol, RC remnant cholesterol, SBP systolic blood pressure