Table 3.

Risk of AVC progression across LDL-C vs RC concordant/discordant groups by LDL-C median and RC median

LDL-C groups	RC groups	Events/No. at risk	Model 1 HR (95% CI)	P value	Model 2 HR (95% CI)	P value	Model 3 HR (95% CI)	P value
LDL-C, mg/dL
< 117.6	–	290/2794	Reference	1.0	Reference	1.0	Reference	1.0
≥ 117.6	–	278/2803	0.972 (0.824–1.147)	0.736	1.060 (0.894–1.257)	0.500	1.057 (0.891–1.254)	0.525
RC, mg/dL
–	< 21.6	245/2786	Reference	1.0	Reference	1.0	Reference	1.0
–	≥ 21.6	323/2811	1.389 (1.171–1.647)	< 0.001	1.284 (1.077–1.531)	0.005	1.280 (1.073–1.527)	0.006
Cut points: LDL-C, 117.6 mg/dL; RC, 21.6 mg/dL
< Cut point	< Cut point	150/1743	Reference	1.0	Reference	1.0	Reference	1.0
	≥ Cut point	140/1051	1.718 (1.359–2.171)	< 0.001	1.529 (1.203–1.945)	0.001	1.528 (1.201–1.943)	0.001
≥ Cut point	< Cut point	95/1043	1.108 (0.856–1.434)	0.434	1.230 (0.948–1.598)	0.119	1.231 (0.948–1.598)	0.119
	≥ Cut point	183/1760	1.287 (1.034–1.603)	0.024	1.295 (1.034–1.621)	0.024	1.289 (1.029–1.616)	0.027

Model 1: Adjusted for age, race and sex. Model 2: Adjusted for Model 1 covariates plus antihypertensive medication use, BMI, drinking status, FG, hypoglycemic medication use, lipid-lowering medication use, SBP and smoking status. Model 3: Adjusted for Model 2 covariates plus CRP and eGFR

AVC aortic valve calcium, BMI body mass index, CI confidence interval, CRP C-reactive protein, eGFR estimate glomerular filtration rate, FG fasting glucose, HDL-C high-density lipoprotein cholesterol, HR hazard ratio, LDL-C low-density lipoprotein cholesterol, RC remnant cholesterol, SBP systolic blood pressure