Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 10;10:2. doi: 10.1186/s42234-023-00134-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Schematic illustration of the experimental design and recording set-up. A The number of animals assigned to each experimental group. B Animals were handled and habituated to the test procedures prior to the experiments. Leads were implanted 8–15 days after pain induction and CL-SCS was administered approximately two days after lead implantation. Responses to mechanical and cold stimuli were assessed in all animals before and after each of the surgical procedures as well as in response to CL-SCS. BS1: baseline assessment of hypersensitivity before spared nerve injury (SNI) induction. BS2: baseline assessment of hypersensitivity before lead implantation. MCS: Multi-Channel-System MkII (Saluda Medical) used for stimulation and recordings, SCS-OFF: spinal cord stimulation off, SCS-ON: spinal cord stimulation on. Created with BioRender.com