Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 10;10:2. doi: 10.1186/s42234-023-00134-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — The effect of closed-loop spinal cord stimulation (CL-SCS) on mechanical (A, B) and cold (C, D) hypersensitivity was assessed using the von Frey and acetone tests. A Mean log10 thresholds (T, in grams) and (C) paw withdrawal latencies before SNI surgery (BS1), before lead implantation (BS2), and at 0, 15, 30, 45 and 60 min after the onset of CL-SCS delivery. The dotted lines represent spared nerve injury (SNI) surgery and lead implantation (IMPL). The pattern in the background represents the time that CL-SCS was delivered. A CL-SCS provided a significant reduction of mechanical hypersensitivity in the SNI SCS-ON animals when compared to the SNI (15 and 30 min: p < 0.001) and SNI SCS-OFF (15 and 30 min: p < 0.001) animals. C CL-SCS provided a significant reduction of cold hypersensitivity in the SNI SCS-ON animals when compared to the SNI SCS-OFF (15 min: p = 0.004, 30 min: p = 0.007) animals. B, D The area under the curve (AUC) for 0–30 min (left panel) and 30–60 min (right panel) time points, summarizing the measurements in (A) and (C). Data are presented as mean ± SEM, n = 6–7. p < 0.05 (corrected) was used as the significance level (one and two-way ANOVA, t-test). * denotes significance compared to SNI SCS-ON. Sham animals received no SNI surgery and no lead implantation (sham), or no stimulation (sham SCS-OFF) or were subjected to CL-SCS (sham SCS-ON). SNI animals received SNI surgery and no lead implantation (SNI), or no stimulation (SNI SCS-OFF) or were subjected to CL-SCS (SNI SCS-ON)