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. 2023 Sep 9;116(1):149–159. doi: 10.1093/jnci/djad183

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Figure 4. — Neuroblastoma patients harboring germline pathogenic or likely pathogenic (P-LP) variants in cancer predisposition genes have worse overall survival. Kaplan–Meier plots of overall survival probability in neuroblastoma patients with and without P-LP variants cancer predisposition genes. A) All patients. B) Restricted to low- and intermediate-risk (non-high-risk) groups. C) Restricted to high-risk group. Statistical significance in panels A-C assessed by log-rank test (P < .05). D) Forest plot of hazard ratios from Cox proportional hazards model. amp = amplified; Dx = diagnosis.