Table 3.
Risk factors associated with a diagnosis of squamous cell carcinoma of the anus following anal intraepithelial neoplasia grade 3 in 11 US states; Puerto Rico; and Washington, DC, 1996-2019a
| Variable | Counts (%) | Events | Cox proportional hazards for risk of death (95% CI) |
P | Subdistribution HR (95% CI) (Squamous cell carcinoma of the anus competing risk regression) |
P |
|---|---|---|---|---|---|---|
| Age at anal intraepithelial neoplasia grade III diagnosis, y | ||||||
| 20-29 | 674 (7.3) | 5 | 0.49 (0.32 to 0.75) | .001 | 0.35 (0.14 to 0.87) | .024 |
| 30-39 | 1595 (17.2) | 42 | 0.94 (0.77 to 1.16) | .586 | 0.96 (0.66 to 1.40) | .830 |
| 40-49 | 2528 (27.4) | 50 | Referent | Referent | ||
| 50-59 | 2574 (27.8) | 53 | 1.21 (1.02 to 1.45) | .033 | 0.77 (0.55 to 1.10) | .150 |
| 60-85 | 1877 (20.3) | 68 | 2.98 (2.51 to 3.53) | < .001 | 1.43 (1.02 to 2.01) | .036 |
| AIDS, HIV status, and sex | ||||||
| Female without HIV | 2813 (30.4) | 84 | Referent | Referent | ||
| Female HIV only | 182 (2.0) | 2 | 0.72 (0.37 to 1.39) | .323 | 0.53 (0.13 to 2.17) | .380 |
| Female with AIDS | 592 (6.4) | 19 | 1.40 (1.07 to 1.84) | .015 | 1.40 (0.85 to 2.33) | .190 |
| Male without HIV | 1706 (18.4) | 40 | 1.22 (1.03 to 1.44) | .021 | 0.91 (0.63 to 1.33) | .640 |
| Male HIV only | 1556 (16.8) | 13 | 0.71 (0.54 to 0.93) | .012 | 0.43 (0.24 to 0.79) | .006 |
| Male with AIDS | 2399 (25.9) | 90 | 1.59 (1.35 to 1.87) | < .001 | 1.57 (1.15 to 2.14) | .005 |
a
CI = confidence interval; HR = hazard ratio.