Table 3.
ROC analysis of predictive factors for CRRT discontinuation and MAKE 90
| CRRT discontinuation |
MAKE 90 |
|||
|---|---|---|---|---|
| AUC [95% CI] | p value | AUC [95% CI] | p value | |
| UV d0 (mL/day) | 0.91 [0.80–0.96] | Reference | 0.59 [0.44–0.73] | Reference |
| Cr at CRRT initiation (mg/dL) | 0.73 [0.59–0.84] | 0.026* | 0.45 [0.32–0.59] | 0.2 |
| eGFR d1 (ml/min/1.73 m2) | 0.77 [0.58–0.88] | 0.15 | 0.47 [0.34–0.61] | 0.17 |
| Cr clearance (mL/min) | 0.86 [0.67–0.95] | 0.52 | 0.64 [0.49–0.77] | 0.51 |
| KeGFR d1 (ml/min/1.73 m2) | 0.75 [0.56–0.88] | 0.14 | 0.49 [0.35–0.63] | 0.26 |
| uL-FABP (μg/gCr) | 0.71 [0.54–0.84] | 0.023* | 0.70 [0.55–0.82] | 0.26 |
| uNGAL (ng/mL) | 0.78 [0.62–0.89] | 0.034* | 0.76 [0.62–0.86] | 0.027* |
| UV d0+KeGFR d1 | 0.92 [0.84–0.97] | 0.42 | ||
| UV d0+KeGFR d1+uL-FABP | 0.95 [0.88–0.98] | 0.19 | ||
| UV d0+KeGFR d1+uNGAL | 0.93 [0.85–0.97] | 0.13 | ||
CRRT, continuous renal replacement therapy; KeGFR, Kinetic eGFR; UV, urine volume; AUC, area under the curve; CI, confidence interval; SE, sensitivity; Sp, specificity; d0, the day of CRRT discontinuation; d1, the following day of CRRT discontinuation.
*
p value <0.05.
**p value <0.01. ***p value <0.001.