Table 2. Characteristics of reported cases of COVID-19 vaccine-induced TCM.

TCM: takotsubo cardiomyopathy, LVEF: left ventricular ejection fraction, M: male, NR: not reported, F: female, ECG: electrocardiography, mRNA: messenger ribonucleic acid

Source: [8,10,13-25]

Author/Year	Age (years)/Sex	Type of vaccine	Dose of vaccine	Days to symptom onset (days)	Symptoms	Troponin level	LVEF (%)	ECG	Hospital stays (day)	Management	Outcome
Reza et al., 2023 [8]	59/F	mRNA-1273	3rd	3	Dyspnea	Elevated	< 50	Abnormal	7	Furosemide, hydrocortisone, norepinephrine	Improved
Minicullo et al., 2023 [10]	54/F	BNT162b2	1st	1	Dyspnea, confusion	Normal	< 50	Abnormal	4	Oxygen, steroids, diuretics	Improved
Beshai et al., 2022 [13]	45/M	mRNA-1273	2nd	3	Chest discomfort	Elevated	< 50	Abnormal	4	NA	Improved
Chen et al., 2023 [14]	67/F	mRNA-1273	1st	7	Palpitation, chest discomfort	Elevated	< 50	Abnormal	7	Bisoprolol, steroids, diuretics	Improved
Yamaura et al., 2022 [15]	30/F	BNT162b2	2nd	2	Cold sweat, chest discomfort	Elevated	< 50	Abnormal	15	The patient was managed without medical therapies	Improved
Tedeschi et al., 2022 [16]	71/F	BNT162b2	1st	1	Dyspnea, chest discomfort	Elevated	< 50	Abnormal	NR	NR	Improved
Gill et al., 2022 [17]	18/M	BNT162b2	2nd	3	Asymptomatic	Elevated	< 50	Abnormal	3	NR	Death
Gill et al., 2022 [17]	18/M	BNT162b2	2nd	4	Asymptomatic	Elevated	< 50	Abnormal	4	NR	Death
Boscolo et al., 2021 [18]	63/F	mRNA-1273	1st	1	Dyspnea, fever	Elevated	< 50	Abnormal	NR	NR	Improved
Jani et al., 2021 [19]	65/F	mRNA-1273	1st	1	Headache, nausea, muscle ache, chest discomfort	Elevated	< 50	Abnormal	NR	Dual antiplatelet, metoprolol succinate,	Improved
Toida et al., 2021 [20]	80/F	BNT162b2	1st	1	Anorexia, generalized fatigue	Elevated	< 50	Abnormal	13	Intravenous fluid, oxygen therapy	Improved
Stewart et al., 2021 [21]	50/F	ChadOX1 nCOV-19	2nd	7	Nausea, chest discomfort	Elevated	< 50	Abnormal	5	Oxygen therapy, dual antiplatelet	Improved
Fearon et al., 2021 [22]	73/F	mRNA-1273	NR	1	Nausea, chest discomfort, dyspnea	Elevated	> 50	Abnormal	8	Diuretics, antiplatelet therapy, metoprolol	Improved
Wardhere et al., 2021 [23]	68/F	mRNA-1273	2nd	7	Chest discomfort	Elevated	< 50	Abnormal	NR	NR	Improved
Crane et al., 2021 [24]	72/M	ChadOX1 nCOV-19	1st	4	Chest pain, fatigue, myalgias, fever	Elevated	< 50	Abnormal	10	Dual antiplatelet therapy, losartan, metoprolol	Improved
Vidula et al., 2021 [25]	60/F	BNT162b2	2nd	4	Chest pain, nausea	Elevated	< 50	Abnormal	NA	metoprolol succinate, lisinopril	Improved