TABLE 4.

Predicted C _min in ng/mL and percentage of simulated subjects achieving C _min ≥ EC50 of 149.68 ng/mL ^a

Dose (mg) plus ritonavir (100 mg)	Time point	Median	Fifth percentile	95th percentile	Min	Participants achieving C min ≥ EC50 (%)
75	First dose	406	195	689	92	99
	Steady state	465	212	881	100	99.5
100	First dose	544	271	880	122	99.8
	Steady state	622	293	1131	131	99.9
150	First dose	807	395	1345	166	100
	Steady state	921	429	1711	179	100
300	First dose	1632	836	2649	415	100
	Steady state	1860	905	3361	445	100

^a C _min, minimum concentration during the dosing interval (12 h); EC50, concentration at which 50% inhibition of viral replication is observed; that is, concentration required for 50% effect.