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. 2023 Dec 8;68(1):e01050-23. doi: 10.1128/aac.01050-23

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Fig 1 — Antiviral effects of PIKfyve inhibitors against influenza isolates. (A) Concentration-dependent cell toxicity and antiviral effects of apilimod mesylate (AM) in MDCK cells infected with H1N1 A/California/07/2009. (B) Concentration-dependent cell toxicity and antiviral effects of YM201636 (YM) in MDCK cells infected with H1N1 A/California/07/2009. (C) Antiviral effects of AM and YM in MDCK cells infected with H3N2, A/Ohio/88/2012 v. (D) Antiviral effects of AM and YM in MDCK cells infected with H5N1, Duck/MN/1525/81. Compounds were treated at the same time when the virus was inoculated, and CPE was determined on Day 3 post-inoculation by neutral red staining.