TABLE 2.
Antiviral effects of PIKfyve inhibitors against other respiratory viruses a
| Virus strain | Apilimod mesylate | YM201636 | Reference | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50
(µM) |
IC90
(µM) |
CC50
(µM) |
SI | IC50
(µM) |
IC90
(µM) |
CC50
(µM) |
SI | IC50
(µM) |
IC90
(µM) |
CC50
(µM) |
SI | ||
| HRV14 | 12.3 | 40.9 | >54 | >4.4 | 7.5 | 23.5 | >21.4 | >2.9 | Pirodavir | 0.003 | 0.019 | 37.9 | 14,000 |
| HRV1B | 0.52 | 2.8 | >54 | >103 | − | − | − | − | Pirodavir | 0.016 | 0.053 | 40.9 | 2,500 |
| hCoV-229E | 0.04 | 0.23 | >54 | >1375 | 4.5 | >21.4 | >21.4 | >4.8 | M128533 b | 0.19 | 1.1 | >10 | >53 |
| hCoV-OC43 | 0.007 | 0.030 | 1.3 | 193 | 0.9 | 4.1 | >21.4 | >25 | M128533 b | 0.12 | 1.1 | >10 | >83 |
| RSV A2 | 19.6 | 44.2 | 29.5 | 1.5 | >21.4 | >21.4 | >21.4 | − | Ribavirin | 8.6 | 53.2 | 2047 | 238 |
| PIV-3 | 31.1 | 52.4 | 18.0 | 0.58 | >21.4 | >21.4 | >21.4 | − | Ribavirin | 73.7 | 356 | 606 | 8.2 |
a
IC50 IC90 = concentration required for 50% and 90% inhibition, respectively, CC50 = concentration to show 50% of cell death. SI: safety index = CC50/IC50.
b
µg/mL