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. Author manuscript; available in PMC: 2024 Jan 10.
Published in final edited form as: J Am Chem Soc. 2023 Sep 6;145(37):20422–20431. doi: 10.1021/jacs.3c05996

Figure 1.

Figure 1.

Completed atomistic level structure for the GLP-1 receptor in complex with the heterotrimeric Gs protein and the ExP5 biased agonist. (A) Side-view depiction. (B) RMSDs for the whole complex, the transmembrane domain, the ligand-binding pocket (all residues in 8.0 Å proximity with respect to ExP5), and the Gs protein. The RMSDs were computed after alignment of the selected components and were referenced against the cryo-EM structure (PDB code: 6B3J).13 All RMSDs are for non-hydrogen backbone atoms.