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. Author manuscript; available in PMC: 2024 Jan 10.
Published in final edited form as: J Am Chem Soc. 2023 Sep 6;145(37):20422–20431. doi: 10.1021/jacs.3c05996

Figure 4.

Figure 4.

Displacements of transmembrane helices of GLP-1R before and after activation. The refined ExP5–GLP-1R–Gs signaling complex (color: ExP5 in green, GLP-1R in white, and Gs protein in pink) was used as the active-state structure, while the inactive structure was extracted from the MD simulation for an apo GLP-1R (color: brown). (A) Front view and residue movements in TM6–7. Selected residues are shown on sticks to indicate their movements upon activation. (B) Extra- and intracellular views for TMD displacements.