CAR |
Chimeric antigen receptor |
TME |
Tumor microenvironment |
ACT |
Adoptive T-cell transfer |
MHC |
Major histocompatibility complex |
TAA |
Tumor-associated antigen |
FasL |
Fas ligand |
TRAIL |
Tumor necrosis factor-related apoptosis-inducing ligand |
FDA |
The Food and Drug Administration |
EMA |
The European Medicines Agency |
EGFR |
Epidermal growth factor receptor |
HER2 |
Human epidermal growth factor receptor 2 |
HNSCC |
Head and neck squamous cell carcinoma |
CEA |
Carcinoembryonic antigen |
PSMA |
Prostate-specific membrane antigen |
scFv |
Single-chain variable fragment |
CD |
Cluster of differentiation |
NSCLC |
Non-small-cell lung cancers |
OS |
Overall survival |
PD-1 |
Programmed cell death-1 |
PFS |
Progression-free survival |
CSD |
Co-stimulatory domain |
IL |
Interleukin |
CRISPR |
Clustered regularly interspaced short palindromic repeats |
TCR |
T-cell receptor |
CLL |
Chronic lymphocytic leukemia |
ALL |
Acute lymphoblastic leukemia |
DLBCL |
Diffuse large B-cell lymphoma |
TNBC |
Triple-negative breast cancer |
TLR4 |
Toll-like receptor 4 |
DCs |
Dendritic cells |
DAMPs |
Damage-associated molecular patterns |
HMGB1 |
High-mobility group box 1 |
IFN-I |
Type I interferon |
Tregs |
Regulatory T cells |
MDSC |
Myeloid-derived suppressor cells |
TGF-β |
Transforming growth factor-Β |
EOC |
Epithelial ovarian cancer |
CTX |
Cyclophosphamide |
M6P |
Mannose-6-phosphate |
HLA |
Human leukocyte antigen |
APCs |
Antigen-presenting cells |
BCMA |
B-Cell maturation antigen |
CPIs |
Checkpoint inhibitors |
DNR |
PD-1 dominant negative receptor |
shRNA |
Short hairpin RNA |
A2ARs |
Adenosine 2A receptors |
CTLA-4 |
Cytotoxic T-lymphocyte associated protein 4 |
PDCD1 |
Programmed cell death protein 1 |
TRAC |
T-Cell receptor alpha constant |
BiTEs |
Bispecific T-Cell engager |
HDAC |
Histone deacetylase |