Table 3.
Top 10 enriched pathways in kidney cancer. Pathway analysis of 248 significantly differentially expressed proteins from kidney cancer was carried out using FunRich.
| No. | Pathway | Number of Proteins from the Dataset |
Proteins from Background Dataset |
p-Value | FDR p-Value |
Altered Proteins from the Dataset |
|---|---|---|---|---|---|---|
| 1 | Metabolism of amino acids and derivatives | 42 | 188 | 1.6903 × 10−12 | 2.819 × 10−9 | DLST; HSD17B10; ACAT1; HIBADH; BCKDHA; GLUD1; GRHPR; HIBCH; ACADSB; ALDH7A1; OGDH; ALDH6A1; ALDH4A1; GATM; ASS1; AGMAT; FTCD; DDC; AUH; QDPR; BBOX1; GOT2; ALDH9A1; GOT1; HPD; DBT; GCDH; MCCC1; DLD; AASS; MCCC2; SHMT1; BCKDHB; OAT; IVD; HGD; HAAO; MRI1; KYNU; PSMB8; PSMB9; PSME2 |
| 2 | Metabolism of lipids and lipoproteins | 40 | 257 | 3.77293 × 10−7 | 0.0006293 | HADHA; ACAT1; UGT1A9; DECR1; IDH1; HADH; ECHS1; LRP2; BDH1; PCCB; GK; PCCA; GPD1; ACADM; AMACR; PLIN2; APOA1; HSPG2; CPT2; ACAA1; GGT5; HMGCL; ACOX1; OXCT1; HMGCS2; CUBN; ACSL1; AMN; SLC27A2; MUT; ECI1; CRAT; P4HB; ACLY; SCARB1; PTGES3; HADHB; TXNRD1; ACADS; HSD3B7 |
| 3 | Fatty acid, triacylglycerol and ketone body metabolism | 25 | 83 | 7.33774 × 10−11 | 1.224 × 10−7 | HADHA; ACAT1; UGT1A9; DECR1; HADH; ECHS1; BDH1; PCCB; GK; PCCA; GPD1 ACADM; PLIN2; CPT2; HMGCL; ACOX1; OXCT1; HMGCS2; ACSL1; MUT; ECI1; ACLY; HADHB; TXNRD1; ACADS |
| 4 | Pyruvate metabolism and citric acid (TCA) cycle | 21 | 31 | 3.72184 × 10−18 | 6.208 × 10−15 | DLST; ACO2; FH; SDHB; PDHB; SUCLG2; OGDH; SUCLG1; IDH2; SDHA; PDHA1; CS; MDH2; DLD; L2HGDH; SUCLA2; NNT; DLAT; PDK2; PDHX; PDK1 |
| 5 | Fatty acid beta-oxidation I | 13 | 19 | 9.29191 × 10−12 | 1.55 × 10−8 | HADHA; HSD17B10; HADH; ECHS1; ACADM; ACAA2; ACAA1; ECI2; EHHADH; ACSL1; SLC27A2; ECI1; HADHB |
| 6 | Glucose metabolism | 12 | 36 | 2.13353 × 10−6 | 0.0035587 | PCK2; GOT2; PGK1; MDH2; GOT1; PC; PCK1; SLC25A10; SLC25A11; MDH1; PYGL; TPI1 |
| 7 | Iron uptake and transport | 12 | 37 | 2.96762 × 10−6 | 0.00495 | ATP6V1E1; ATP6V1A; ATP6V1H; ATP6V1B1; ATP6V1G1; ATP6V1F; ATP6V1B2; ATP6V0A1; ATP6V1C1; ATP6V0D1; HMOX1; TF |
| 8 | Mitochondrial fatty acid beta-oxidation | 11 | 14 | 3.49111 × 10−11 | 5.823 × 10−8 | HADHA; DECR1; HADH; ECHS1; PCCB; PCCA; ACADM; MUT; ECI1; HADHB; ACADS |
| 9 | Gluconeogenesis | 11 | 20 | 1.10997 × 10−8 | 1.851 × 10−5 | PCK2; GOT2; PGK1; MDH2; GOT1; PC; PCK1; SLC25A10; SLC25A11; MDH1; TPI1 |
| 10 | Transferrin endocytosis and recycling | 11 | 27 | 5.58496 × 10−7 | 0.0009316 | ATP6V1E1; ATP6V1A; ATP6V1H; ATP6V1B1; ATP6V1G1; ATP6V1F; ATP6V1B2; ATP6V0A1; ATP6V1C1; ATP6V0D1; TF |