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. 2023 Dec 20;64(1):42–56. doi: 10.1021/acs.jcim.3c01524

Table 1. Factors Influencing Yield of a Chemical Reaction.

Factors Influencing Yield Explanation
Low Reactivity Reactants may not fully react, resulting in a low yield of the desired product.
Side Reactions Other thermodynamically possible reaction paths may be followed, leading to side products and lower yield.
Reactant/Reagent/ Catalyst Deactivation Deactivation of reactants, reagents, or catalysts caused by other reaction system components.
Thermodynamic and Kinetic Factors Reaction conditions (temperature, pressure, concentration, etc.) can affect the reaction rate and yield.
Contaminants Impurities in reactants or reagents can interfere with the reaction and reduce the yield.
Sensitivity to Environment Reactions may be sensitive to environmental factors like air, moisture, or light.
Product Degradation/ Reactivity The desired product may be too reactive or unstable, leading to further reactions or degradation.
Product Isolation Difficulties in isolation or purification of the product can result in a lower yield.