Table 2.

Definition of PD-L1 and TAMs.

Correlation of TAMS and PD-L1
	Author	Definition of PD-L1	Definition of TAMS	Method of Analysis
1	Ubukata Y (2020) [39]	No/low and high expression	CD163 level was determined	Immunohistochemistry
2	Ju X (2020) [40]	0 (no staining), 1 (weak staining), 2 (moderate to intense staining).	CD68 in macrophage was scored as 1 (<1%), 2 (1–9%), 3, or 4 (>20%)	Immunohistochemistry
3	Junttila A (2020) [41]	PD-L1 CPS was ≤1% or >1%/Divided into two groups	Clever-1 was defined to be high when median ≥ 15 in macrophages	Immunohistochemistry
4	Huang Y.K (2019) [42]	Low or high expression	Macrophages were CD68 positive/M1-like TAM populations were identified based on the absence of CD163 and CD206/M2-like TAM populations were identified by the presence of CD163 and/or CD206	Immunohistochemistry
5	Harada K (2017) [43]	PD-L1 positive if >1% of tumor cells expressed PD-L1	The density of CD68- and CD163-positive cells was evaluated	Immunohistochemistry
6	Zhang H (2022) [44]	Positive or negative PD-L1 expression	For the CD68+ macrophages density, ≤66/HPF (at ×200 magnification) was defined as low and ≥67/HPF was defined as high/For the IL-10+ CD68+ cells density, ≤9/HPF was defined as low and ≥10/HPF was defined as high.	Immunohistochemistry
7	Ivanovic T (2023) [45]	PD-L1-positive tumor cells estimated as negative (0), low	The density of macrophage infiltration was valued as 0 (no infiltration), 1 (sparse), 2 (peripheral) and 3 (dense and intermingled with tumor cells)	Immunohistochemistry