Table 1.

Clinico-pathological characteristics of the series and relations between microsatellite stable tumors (MSS) and microsatellite instable tumors (MSI).

	All (n = 403)	MSS (n = 351)	MSI (n = 52)	p Value a
Age (years) b				0.55
≤68 years	221	190	31
>68 years	182	161	21
Gender				0.34
Male	207	184	23
Female	196	167	29
Tumor Site c				0.005
Right Colon	145	115	30
Left Colon	145	134	11
Rectum	113	102	11
Serum CEA Levels				0.98
≤3.5 ng/mL	237	207	30
>3.5 ng/mL	166	144	22
Performance Status				0.69
0	120	102	18
1	203	178	25
2	80	71	9
NPS d				0.79
0	76	67	9
1	211	185	26
2	116	99	17
Tumor Size b				0.87
≤4 cm	240	208	32
>4 cm	163	143	20
pT Stage				0.48
0	9	8	1
1	22	20	2
2	82	73	9
3	217	187	30
4a	65	56	9
4b	8	7	1
1–2	113	101	12	0.49
3–4	290	250	40
pN Stage				0.62
0	245	215	30
1a	46	40	6
1b	48	42	6
1c	13	11	2
2a	15	12	3
2b	27	22	5
Nx	9	9	0
Node Negative	245	215	30	0.73
Node Positive	149	127	22
pM Stage				0.08
0	314	278	36
1a	66	55	11
1b	10	8	2
1c	13	10	3
M−	314	278	36	0.15
M+	89	73	16
TNM Stage				0.44
0–II	225	199	26
III–IV	178	152	26
Dukes’s Stage				0.21
A	99	88	11
B	126	111	15
C	89	79	10
D	89	73	16
Histologic Differentiation				0.26
well	8	8	0
moderate	353	309	44
poor	42	34	8
Radical Resection				0.47
Yes	339	293	46
No	64	58	6
PostOperative Complications				0.31
No	361	317	44
Yes	42	34	8
Postoperative Chemotherapy				0.99
No	190	166	24
Yes	213	185	28
Tumor Recurrence e				0.70
No	284	249	35
Yes	119	102	17
Survival				0.24
Yes	280	248	32
No	123	103	20

p value refers to MSS vs. MSI tumors; CEA indicates carcinoembryonic antigen (3.5 ng/mL normal value in healthy subjects); Postoperative complications were defined as grade II or higher of the Clavien-Dindo classification [27]. ^a chi-square test. ^b median value in all series. ^c right colon means cecum, the ascendent colon, and the right transverse colon; the left colon means left. transverse colon, descendent colon, and sigma. ^d Naples Prognostic Score (reference n° 21). ^e including 64 non-radical operations.