Table 1.

Concise summary of the various aspects related to metastasis in endometrial cancer.

Aspect	Summary
Metastasis Elements	Disturbances in cell-ECM adhesion, cytoskeleton disruptions, and invasive properties are crucial in cancer metastasis.
Influence of Estrogen	Estrogen affects actin and cell membranes, increasing migration and implantation capabilities in endometrial cells.
Role of Prolactin	Prolactin has complex actions, including anti-apoptotic effects, proliferation stimulation, and angiogenic influence in EC.
Involvement of Adipocytokines	Adipocytokines like leptin, visfatin, and resistin contribute to the progression and spread of endometrial cancer cells.
SDF-1 and Kisspeptin-10	SDF-1 plays a crucial role in EC metastasis, and kisspeptin-10 therapy shows promise as a metastasis inhibitor (in vitro).
MicroRNAs (miRNAs)	Abnormal miRNA expression, such as miR-199a/b 5p and miR-29a-3p, is linked to EC metastasis, and profiles are under development.
RUNX1 and Metastasis	Overexpression of the transcription factor RUNX1 is associated with EC lung and nodal metastasis.