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Overview of the Canonical Nuclear Import Mechanism. The nuclear cargo (highlighted in orange) harbors a nuclear localization signal (NLS) (depicted in yellow). The NLS is bound by importin-α (colored blue), and importin-β (shown in green) binds importin-α through the IBB domain. The trimeric assembly translocates through the nuclear pore complex into the nucleus, where upon entry, RanGTP (colored black) binds importin-β, mediating disassembly of the complex and the release of cargo.
