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. 2023 Dec 29;13(1):71. doi: 10.3390/cells13010071

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Classification of Human Importin Alpha Isoforms The seven human importin alpha isoforms are grouped into three subfamilies (SF-1, SF-2, and SF-3) according to their sequence similarities. Subfamily SF-1 includes IMPA1 and IMPA8, which exhibit the lowest sequence identity among the subfamilies. Subfamily SF-2, with the highest sequence homology, consists of IMPA3 and IMPA4. Subfamily SF-3 comprises IMPA5, IMPA6, and IMPA7. The specific sequence identity percentages, calculated using BLAST, are indicated for each isoform to the right of the figure.