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Ebola VP24 inhibits STAT1 signaling by binding SF-3 IMPAs. (A) IMPAs are comprised of 10 armadillo (ARM) repeats of 3 helices (PDB 1BK5). cNLS and ncNLS sites are indicated. (B) VP24 functions as a competitive inhibitor of STAT1-IMPA interaction by blocking phosphorylated STAT1 (PY-STAT1) binding via its ncNLS to IMPA (PDB 1BK5, 4U2X, and 1BF5).
