Table 3.

Somatostatin analogues and their affinities for somatostatin receptors.

Somatostatin Analogue	Affinity for Somatostatin Receptors	Selectivity	Duration of Action	Application in NET
Octreotide	SSTR2 > SSTR5 > SSTR3 > SSTR1 > SSTR4	high	Long	Symptom control, growth inhibition, and hormone control in pancreatic, intestinal, lung, neck, and thyroid NET
Lanreotide	SSTR2 = SSTR5 > SSTR3 > SSTR1 > SSTR4	high	Long	Symptom control, growth inhibition, and hormone control in pancreatic, intestinal, lung, and neck NET
Pasireotide	SSTR5 > SSTR2 > SSTR3 > SSTR1 > SSTR4	high	Long	Symptom control, growth inhibition, and hormone control in pancreatic and intestinal NET
Vapreotide	SSTR2 > SSTR5 > SSTR3 > SSTR1 > SSTR4	high	Short	Diagnosis and assessment of somatostatin receptors in NETs
Somatuline	SSTR2 > SSTR5 > SSTR3 > SSTR1 > SSTR4	high	Medium	Symptom control, growth inhibition, and hormone control in pancreatic, intestinal, lung, neck, and thyroid NET