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. 2023 Dec 29;16(1):168. doi: 10.3390/cancers16010168

Figure 4.

Figure 4

AdCAR treatment of luciferase- and GFP-expressing MBC-PDO #07 at various E:T ratios. (A) Fluorescence images of GFP-expressing MBC-PDO #07 treated with AdCAR-T cells of different E:T ratios with the addition of LLE-CD276 mAb over 72 h. Scale bar: 500 µm. (B) Target cell lysis of MBC-PDO #07 treated with AdCAR-T cells with (black bars) and without (gray bars) LLE-CD276 mAb over 72 h. Target cell lysis efficiency was determined by luciferase activity of viable organoids. Data shown represent the mean ± SD of biological triplicates (n = 3). Negative values were set to 0. Statistical analysis was performed using paired t-test. ns, not significant. * = p ≤ 0.05; ** = p ≤ 0.01; *** = p ≤ 0.001.