Table 1.
Baseline characteristics among patients with RET fusion-positive aNSCLC.
| (n {%}) Unless Specified | Pre-Matched | Genetic Matching | ||||
|---|---|---|---|---|---|---|
| Selpercatinib Arm (n = 69) | Comparator Arm (n = 246) |
p-Value | Selpercatinib Arm (n = 68) |
Comparator Arm (n = 68) |
p-Value | |
| Age at index date, year | ||||||
| Mean (SD) | 62.1 (13.0) | 56.9 (11.4) | 0.0014 | 62.2 (13.1) | 61.0 (10.8) | 0.5836 |
| Sex | ||||||
| Female | 43 (62.3) | 140 (56.7) | 0.4016 | 43 (63.2) | 43 (63.2) | 1.0000 |
| Male | 26 (37.7) | 107 (43.3) | 25 (36.8) | 25 (36.8) | ||
| Race | ||||||
| White | 48 (69.6) | 108 (43.7) | 0.0005 | 47 (69.1) | 48 (70.6) | |
| Black/African American | 4 (5.8) | 12 (4.9) | 4 (5.9) | 4 (5.9) | 0.9847 | |
| Asian | 13 (18.8) | 118 (47.8) | 13 (19.1) | 13 (19.1) | ||
| Other | 4 (5.8) | 7 (2.8) | 4 (5.9) | 3 (4.4) | ||
| Time from initial diagnosis to 1L start | ||||||
| Q1 | 1 (1.5) | 81 (32.8) | 1 (1.5) | 1 (1.5) | ||
| Q2 | 6 (8.7) | 70 (28.3) | <0.0001 | 6 (8.8) | 6 (8.8) | 0.9870 |
| Q3 | 23 (33.3) | 53 (21.5) | 23 (33.8) | 25 (36.8) | ||
| Q4 | 39 (56.5) | 42 (17.0) | 38 (55.9) | 36 (52.9) | ||
| Stage at initial diagnosis | ||||||
| Stage I-IIIA | 3 (4.4) | 12 (4.9) | 3 (4.4) | 3 (4.4) | 1.000 | |
| Stage IIIB-IV | 65 (94.2) | 235 (95.1) | 0.1641 | 65 (95.6) | 65 (95.6) | |
| Unknown | 1 (1.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||
| ECOG Performance Status | ||||||
| 0/1 | 65 (94.2) | 240 (97.2) | 0.2352 | 64 (94.1) | 64 (94.1) | 1.000 |
| 2 | 4 (5.8) | 7 (2.8) | 4 (5.9) | 4 (5.9) | ||
| Smoking Status, no | 48 (69.6) | 165 (66.8) | 0.6650 | 47 (69.1) | 45 (66.2) | 0.7139 |
| Brain metastases, yes | 16 (23.2) | 77 (31.2) | 0.1981 | 16 (23.5) | 16 (23.5) | 1.0000 |
Abbreviations: aNSCLC, advanced non-small cell lung cancer; ECOG, European Cooperative Oncology Group; n, number of patients in sub-group; Q1, 1st quartile; Q2, 2nd quartile; Q3, 3rd quartile; Q4, 4th quartile; 1L, first-line therapy; and SD, standard deviation. Notes: Statistical comparisons between treatment arms were computed using t-tests for continuous variables and Chi-square and Fisher’s exact test for categorical variables. Bold text indicates statistically significant differences between the treatment arms.