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. 2023 Dec 20;25(1):83. doi: 10.3390/ijms25010083

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PPP inhibits UVB-induced wrinkle formation in dorsal skin tissue of SKH-1 mice. (A) Relative wrinkle formation images obtained from silicon replicas and relative roughness average was calculated by Image J software. (B) The collagen of the dermal layer was stained as a blue by Masson’s trichrome staining, and relative collagen intensity was calculated by Image J software. (C) The expression of MMP-1 in the dorsal skin was measured by immunohistochemistry. (D) Epidermal thickness was observed by H&E staining and calculated by Image J software. The blue bars indicate the epidermis. (E) The expression of MMP-1 and MMP-2 in dorsal skin was determined by Western blotting analysis. (F) The level of COL7A1 mRNA was investigated by quantitative real-time PCR. Statistical significance indicated ^# p < 0.05; ^### p < 0.001 compared with the untreated group and * p < 0.05; *** p < 0.001 compared with the UVB-irradiated group.