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. 2023 Dec 21;25(1):166. doi: 10.3390/ijms25010166

Figure 3.

Figure 3

Data generated from Far-UV CD spectra for hACE2-derived peptides measured at a concentration of 100 µM in 10 mM sodium phosphate buffer at pH 7.4 and 25 °C. (A) Far-UV CD spectra of hACE2 (Asp30-Asp38)-derived linear and i, i + 4 staple peptides in molar ellipticity per residue. (B) Table listing the derivatives of 1 with a focus on the macrocyclization technique and measure-based calculated helicity (%) via CD. (C) CD spectra of hACE2 (His34-Gln42)-derived linear and i, i + 4 staple peptides in molar ellipticity per residue. (D) Table listing the derivatives of 2 with a focus on the macrocyclization technique and measure-based calculated helicity (%) via CD. HDY 1,5-Hexadiyne; BMB 1,4-Bis(bromomethyl)benzene; HFB hexafluorobenzene. a Predicted helicity (%) using AGADIR online software available at http://agadir.crg.es (accessed on 17 April 2023); it is only applicable to peptides consisting of natural amino acids.