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. 2023 Dec 19;25(1):15. doi: 10.3390/ijms25010015

Figure 2.

Figure 2

Functional changes in HRPs and HRECs exposed to microglia-derived EVs: (a) HRP and (b) HREC proliferation; (c) HRP and (d) HREC apoptosis; (e) HRP and (f) HREC migration: (g) HRP and (h) HREC ROS production. Blue bars: cells exposed to EVs extracted from the supernatants of microglial cells cultured in physiological conditions (EV-mediated bars) or directly cultured in physiological conditions (M1-direct bars); red bars: cells exposed to EVs extracted from the supernatants of M1-activated microglial cells (EV-mediated bars) or directly cultured in the presence of the M1 cocktail (M1-direct); green bars: cells exposed to EVs extracted from the supernatants of microglial cells cultured with thiamine (EV-mediated bars) or directly cultured with thiamine (M1-direct bars); purple bars: cells exposed to EVs extracted from the supernatants of microglial cells cultured in M1 plus thiamine (EV-mediates bars) or directly with M1 plus thiamine (M1-direct bars). Mean ± SD of 5 independent experiments. * = p < 0.05 vs. ctrl and M1+T; $ = p < 0.005 vs. ctrl and M1+T; # = p < 0.05 vs. ctrl and M1.