Table 1.
Description, for each follicle stage group, of the top 5 genes differentially expressed along folliculogenesis reaching their peak expression at this stage. Their function was retrieved and simplified from Uniprot database.
| Gene | Timing of Peak Expression | Full Name | Function (Uniprot Description) |
|---|---|---|---|
| BCOR | Primordial Primary |
BCL6 Interacting Corepressor | Transcriptional corepressor May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3 |
| LOXL2 | Primordial Primary |
Lysyl oxidase homolog 2 | Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine Acts as a transcription corepressor and specifically mediates deamination of H3K4me3, a specific tag for epigenetic transcriptional activation |
| OAZ1 | Primordial Primary |
Ornithine decarboxylase antizyme 1 | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels |
| KRT19 | Primordial Primary |
Keratin, type I cytoskeletal 19 | Involved in the organization of myofibers |
| HIST2H2AA3 | Primordial Primary |
Histone H2A type 2-A | Core component of nucleosome |
| AC034236.1 | Secondary | Unknown | |
| POMZP3 | Secondary | POM121 and ZP3 fusion protein | Unknown |
| MT-CO3 | Secondary | Cytochrome c oxidase subunit 3 | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation |
| COX7B | Secondary | Cytochrome c oxidase subunit 7B, mitochondrial | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation |
| JUND | Secondary | Transcription factor JunD | Transcription factor binding AP-1 sites |
| TUBA1C | Antral | Tubulin alpha-1C chain | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers |
| TUBB8P10 | Antral | Tubulin Beta 8 Class VIII Pseudogene 10 | Pseudogene |
| ZAR1L | Antral | Protein ZAR1-like | mRNA-binding protein required for maternal mRNA storage, translation, and degradation during oocyte maturation Probably promotes formation of some phase-separated membraneless compartment that stores maternal mRNAs in oocytes: acts by undergoing liquid–liquid phase separation upon binding to maternal mRNAs |
| PCBP1 | Antral | Poly(rC)-binding protein 1 | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC |
| WEE2 | Antral | Wee1-like protein kinase 2 | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage Also required for metaphase II exit during egg activation |