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Apigenin (APG) inhibits metastasis and angiogenesis by modulating signaling pathways (MAPK, Akt, NF-κB) and the expression of their target genes (MMPs, snail, twist, β-catenin) associated with epithelial–mesenchymal transition [1]. Furthermore, APG downregulates HiF-1α and VEGF/VEGFR in the tumor environment.
