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The fate of mature MVBs. Mature MVBs face three “fates”: MVBs fuse with lysosomes to transport ubiquitination-modified proteins to lysosomes for degradation and recycling; MVBs fuse with the plasma membrane to secret exosomes; MVBs can also fuse with autophagosomes to form amphisomes, which can both fuse with lysosomes to be degraded and with the plasma membrane to secrete exosomes. (By Figdraw. Hangzhou, Duotai. Technology Co., Ltd., Hangzhou 310000, China).
