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. 2023 Dec 23;25(1):232. doi: 10.3390/ijms25010232

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of low-dose CUR and RES on tumor cell survival. Cell survival was evaluated by the SRB assay on a panel of tumor cell lines including the head and neck carcinoma (SCC-15, A253), breast cancer (MCF-7, MDA-MB-468), malignant mesothelioma (MM-B1, MM-F1, H-Meso-1), prostate cancer (DU 145, PC-3) and colon cancer (HCT 116) cell lines, after 96 h of treatment with DMSO or CUR and/or RES at 5 and 25 µM. The percentage survival of polyphenol-treated cells was calculated relative to that of DMSO-treated control cells. Results are expressed as the mean ± SD of three independent experiments performed in triplicate. Statistical significance was calculated with one-way ANOVA (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001). The effect of CUR, RES, and CUR + RES 25 µM vs. DMSO was always significant.