Figure 5.

SHP-1-mediated regulation in the tumor microenvironment. SHP-1 blocks T cell activation by negatively regulating TCR signaling through binding to the ITSM site and ITIM domain of the coinhibitory molecules, PD-1 and BTLA, respectively. APC—antigen-presenting cell; LAG—lymphocyte-activating gene 3; LCK—lymphocyte-cell-specific protein-tyrosine kinase; ZAP70—zeta-chain-associated protein kinase 70; PD1—programmed cell death protein 1; HVEM—herpes virus entry mediator; BTLA—B and T-lymphocyte attenuator.