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. 2023 Dec 21;25(1):141. doi: 10.3390/ijms25010141

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Restoration of CD4- and CD8-positive T lymphocytes in the spleen of CPA-induced immunosuppressed mice. (a,b) Representative immunohistochemical staining images and (c,d) fold changes of CD4⁺ and CD8⁺ cells in CPA-treated mouse spleen. Scale bar: 75 μm. N, naïve mouse; C, CPA (100 mg/kg)-treated mouse; 10⁸, CPA-treated mouse administered with 10⁸ CFU/kg of KBL346; 10¹⁰, CPA-treated mouse administered with 10¹⁰ CFU/kg of KBL346; PC, positive control group administered with red ginseng (100 mg/kg). * Significant difference compared with the naïve group (*** p < 0.001). ^# Significant difference compared with the CPA-treated control group (^### p < 0.001).

Restoration of CD4- and CD8-positive T lymphocytes in the spleen of CPA-induced immunosuppressed mice. (a,b) Representative immunohistochemical staining images and (c,d) fold changes of CD4⁺ and CD8⁺ cells in CPA-treated mouse spleen. Scale bar: 75 μm. N, naïve mouse; C, CPA (100 mg/kg)-treated mouse; 10⁸, CPA-treated mouse administered with 10⁸ CFU/kg of KBL346; 10¹⁰, CPA-treated mouse administered with 10¹⁰ CFU/kg of KBL346; PC, positive control group administered with red ginseng (100 mg/kg). * Significant difference compared with the naïve group (*** p < 0.001). ^# Significant difference compared with the CPA-treated control group (^### p < 0.001).