Figure 15.

Schematic representation of palmitate effect on VWF gene expression and vWF maturation by NF-κB signalling, palmitate-induced upregulation of CD36, TLR6, and TIRAP as alternative signalling of inhibited TLR4, and compensatory effects between TLR2 and TLR4 in endothelial cells. TLR2 inhibition results in increased TLR4 activity and decrease of TLR2 protein level by silencing results in increased TLR4 protein level. Silencing of TLR4, even if it is only effective at the mRNA level and not the protein level, increases TLR2 protein levels.