Figure 4.

Levels of (A) mRNA and (B) protein of HSP90B in HIP of rats subjected to the CMS (stress) for 8 weeks and simultaneously treated with IMI (10 mg/kg, ip) for the last 5 weeks. Results determined by real-time PCR and Western blot. Rats were sacrificed 24 h after the last administration of IMI or saline (sal). Results are expressed as a percentage of sham/sal group ± standard error of mean (SEM), n = 6; (C) representative blots; * p < 0.05 relative to sham/sal; + p < 0.05 relative to stress/sal group; stress/IMI resp—group of CMS rats that responded to IMI treatment (reversed anhedonia in sucrose test); stress/IMI nonresp—group of CMS rats that did not respond to IMI.