Figure 2.
The role of YAP/TAZ in regulating glycolytic reprogramming in lung fibrosis. The integrin–FAK–YAP/TAZ signal axis promotes the expression of marker genes for lung fibrosis. YAP/TAZ promotes enhanced glycolysis in cells, and the enhanced glycolysis strengthens the nuclear translocation of YAP/TAZ. Additionally, the key glycolytic enzyme HK2 is necessary for the nuclear translocation of YAP/TAZ. PFK1 can bind to TEADs and promote their functional and biochemical cooperation with YAP/TAZ.