Table 2.

Summary of mutations in individual amino acid residues of the receptor-binding domain in selected variants of the SARS-CoV-2 virus [40], together with the residues identified in the intermediate state of RBD–ACE2 complex. The first identified version of SARS-CoV-2 was called wt (wild type). The column labeled wt-6LZG contains residues located on the RBD–ACE2 interface taken from the experimental structure (PDB ID: 6LZG).

Mutations Identified in the RBD					Residues Located on the RBD–ACE2 Interface in the Intermediate State
α	β	γ	δ	o	wt-6LZG	wt	α	β	γ	δ	o
				339, G→D
				371, S→L
				373, S→P
				375, S→F
						R403	R403	R403	R403	R403	R403
								D405	D405	D405
											E406
									R408
								Q409
								Q414
								T415
	417, K→N	417, K→T		417, K→N	K417	K417	K417	N417	T417	K417	N417
							I418	I418
							Y421
				440, N→K
				446, G→S
					N478			N448	N448	N448	N448
			452, L→R
					Y453		Y453				Y453
					L455	L455	L455	L455	L455	L455	L455
					F456	F456	F456
								R457	R457	R457	R457
							T470			T470
					Y473			Y473
				477, S→N				S477
				478, T→K					T478
									N481	N481	N481
						V483	V483			V483	V483
	484, E→K	484, E→K		484, E→A	E484	E484	E484	K484	K484	E484	A484
					F486	F486	F486	F486	F486	F486	F486
			487, T→K		N487	N487		N487			N487
					Y489	Y489	Y489	Y489	Y489	Y489	Y489
							F490		F490	F490	F490
							P491
						L492	L492			L492	L492
				493, Q→R	Q493	Q493					R493
						S494		S494		S494
						Y495	Y495	Y495	Y495	Y495	Y495
				496, G→S
							F497
				498, Q→R	Q498	Q498			Q498	Q498	R498
					T500					T500
501, N→Y	501, N→Y	501, N→Y		501, N→Y	N501		Y501	Y501	Y501	Y501	Y501
								V503
				505, Y→H	Y505	Y505	Y505	Y505	Y505	Y505	H505