Table 5.

Allergenic components of Hevea brasiliensis latex (Hev b) and their clinical relevance. Adapted from MAUG 2 (Molecular Allergology Users’ Guide 2) available online: https://hub.eaaci.org/resources_guidelines/molecular-allergology-users-guide-2-0/, accessed on 1 June 2022.

Allergen	Common Name	Molecolar Weight (kDa)	Relevance as an Allergen for Latex Glove Users	Relevance as an Allergen for Spina Bifida
Hev b 1	Rubber elongation factor β-1,3-glucanase	14	Minor	Major
Hev b 2	β-1,3-glucanase	34	Minor	Minor
Hev b 3	Small rubber protein particle	24	Minor	Major
Hev b 4	Lecithinase homologue	53–55	Minor	Minor
Hev b 5	Acidic structural protein	16	Major	Major/Minor
Hev b 6.01	Prohevein (precursor of hevein Hev b 6.02, the major IgE binding domain)	20	Major	Minor
Hev b 7	Patatin-like protein (esterase) from latex-B- and C-serum (two isoforms: Hev b 7.01 and Hev b 7.02)	44	Minor	Minor
Hev b 8	Profilin (actin-binding protein) (several isoforms and variants)	14	Minor	Minor
Hev b 9	Enolase	51	Minor	Minor
Hev b 10	Manganese superoxide dismutase	26	Minor	Minor
Hev b 11	Class I chitinase	30	Minor	Minor
Hev b 12	Non-specific lipid transfer protein type 1 (nsLTP1)	9	Minor	Minor
Hev b 13	Esterase	42	Minor	Minor
Hev b 14	Hevamine	30	Minor	Minor
Hev b 15	Serine protease inhibitor	7.5	Minor	Minor