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. 2023 Dec 30;13(1):227. doi: 10.3390/jcm13010227

Figure 1.

Figure 1

Cannabinoids block viral entry of SARS-CoV-2 through (1) downregulating ACE2 expression, preventing viral fusion, and (2) downregulating TMPRSS2, preventing the cleavage of ACE2. Abbreviations: ACE2, angiotensin-converting enzyme 2; TMPRSS2, type II transmembrane serine protease. Figure created with BioRender.com (accessed on 17 November 2023).