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SARS-CoV-2 infection reduces ACE2 expression, leading to an accumulation of angiotensin II, which then binds AT1R and induces ROS production through NADPH oxidase. Cannabinoids have been shown to prevent the formation of ROS produced by NADPH. Abbreviations: ACE2, angiotensin-converting enzyme 2; ROS, reactive oxygen species; AT1R, angiotensin II type 1 receptor; NADPH, nicotinamide adenine dinucleotide phosphate. Figure created with BioRender.com.
